The regenerative effect of stem cells on acetaminophen-induced hepatotoxicity in male albino rats

Abstract Background Acetaminophen overdose is the leading cause of acute liver injury (ALI) and failure (ALF) in developed world. We aimed at studying therapeutic potential bone marrow mesenchymal stem cells (MSCs) accelerating healing acetaminophen-induced hepatotoxicity. Results This prospective study included 50 male albino rats divided into 2 groups: hepatotoxic group non-hepatotoxic group. Hepatotoxicity was induced experimental by acetaminophen then were transplanted their effects on assessed. After injection BM MSCs, reached targeted tissues. They established central veins blood sinusoids tissue. The showed degeneration loss normal hepatic architecture as well necrotic areas congestion mainly portal tract vessels, dilation sinusoids, infiltration inflammatory around veins. In addition, there abnormal nuclei either irregular shape or showing open face compared to control tissue MSC-treated restoration Conclusion Administration MSCs has hepato-therapeutic effect hepatotoxicity rats. mechanism this hepatoprotective may be through anti-inflammatory, anti-apoptotic, immunomodulatory actions MSCs.